Vitamin K1 2,3- epoxide

Description: 
Liquid chromatography mass spectrometry (LC-MS/MS) for the determination of Vitamin K1

Due to the relocation of the Nutristasis service to the Blackfriars Hub site, this test is not currently accredited by UKAS to ISO15189
Clinical details: 
Vitamin K1 2,3-epoxide is the bi-product of vitamin K1 formed when vitamin K is used as a cofactor in protein modification. Normally vitamin K epoxide is rapidly recycled by the enzyme vitamin K epoxide reductase (VKOR) and is not normally detectable in blood. If the action of the VKOR enzyme is blocked by vitamin K antagonist type anticoagulants such as warfarin or rodenticide superwarfarins vitamin K1 2,3-epoxide accumulates and becomes detectable in the blood.
Related condition or disease: 
Vitamin K antagonist exposure
Reference range: 

<0.12 ug/L

Synonyms or keywords: 
Vitamin K epoxide
Units: 
ug/L
Department: 
Reference Chemistry
Location: 
Blackfriars Hub
Sample type and Volume required: 
SST
Call in advance: 
No
Turnaround time: 
10 days
Special sample instructions: 

Protect from light.

Criteria for acceptance / rejections of sample
Storage and transport: 
Sample must be protected from light, first class post
Contacts:
Nutristasis Unit at Blackfriars Hub
0204 591 0055
Nutristasis@synnovis.co.uk
Reference Chemistry, 1st Floor Blackfriars Hub
Friars Bridge Court
Blackfriars Road
London
SE1 8NZ

Laboratory opening times
Monday - Friday 09.00 - 17.00
For clinical advice or interpretation of results, please contact the laboratory in the first instance.
Laboratory: 
Nutristasis Unit at Blackfriars Hub

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Last updated: 22/10/2025