Haemoglobinopathy Screen
Description:
The haemoglobinopathy screen by HPLC is used in conjuction with clinical details and results of the FBC to identify Haemoglobin variants and thalassaemias. All Hb variants detected are confirmed by a secondary method. This screen is commonly used in antenatal screening, pre-operative screening and to provide HbS% for transfused sickle cell patients.
Clinical details:
Screen for haemoglobin variants and thalassaemias
Reference range:
HbA2 1.8 - 3.4% of total Hb (adults only). HbF ≤1.5% of total Hb (adults only)
Synonyms or keywords:
Sickle test, HbS%, Hb electrophoresis, haemoglobin electrophoresis, thalassaemia screen, SICK, HPLC, haemoglobinopathy, variant identification, sickle, antenatal screen, HbF%
Department:
Location:
Sample type and Volume required:
Whole blood in EDTA. Required volume is variable as secondary testing may be required. The minimum acceptable volume of whole blood is 1mL.
Turnaround time:
3 working days
Special sample instructions:
Referred in samples must be fully labelled and accompanied with a completed referral request form. A copy of the referral form can be located in the FURTHER INFO tab. Please provide the FBC result, antenatal status and family origins.
Storage and transport:
Blood should be stored at 4°C where possible and may be transported at ambient temperature.
Contacts:
For clinical advice or interpretation of results, please contact the laboratory in the first instance.
Laboratory:
Last updated: 25/06/2026
