Adalimumab
Description:
The measurement of Adalimumab is a useful tool in managing patients who fail to respond (primary failure) or who go on to lose response (secondary failure) to treatment. Monitoring drug levels allows for a personalised approach to drug optimisation by appropriate dose escalation/de-escalation or drug switching/withdrawal.
Measured alone or as part of a profile including anti-Adalimumab antibodies.
Measured alone or as part of a profile including anti-Adalimumab antibodies.
Clinical details:
Adalimumab is a fully humanised monoclonal antibody which specifically targets tumour necrosis factor alpha (TNFα). Adalimumab is licensed for use in Gastroenterology (Crohn's diseases, ulcerative colitis), Rheumatology (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, juvenile idiopathic arthritis) and Dermatology (sever plaque psoriasis). Due to its high cost, Adalimumab is only indicated in patients with severe disease which is refractory to conventional therapeutic approaches.
Reference range:
N/A - Refer to User Information for target drug concentrations - Test interpretation requires full clinical information: drug dosage/frequency, previous exposure to other biologics, time of sampling, duration of therapy and clinical assessment
Units:
µg/mL
Department:
Location:
Sample type and Volume required:
Serum (SST tube or plain) sample is preferred. Plasma (Lithium heparin, citrate or EDTA) is also acceptable. Minimum 300μL serum or plasma required for both drug and anti-drug antibody analysis.
Turnaround time:
2 weeks
Special sample instructions:
Collect blood into a serum separation (SST™) or plain tube, preferably shortly before drug administration (trough levels). Centrifuge sample at 3000 rpm for 10 minutes, aliquot serum or plasma and keep in fridge until transport. If transport is going to be delayed by > 5 days, freeze at -20°C and send by first class post at a later date.
Storage and transport:
Post the sample to Synnovis Central Specimen Reception by first class post (see request form for full address).
Contacts:
Reference Chemistry Laboratory at Blackfriars Hub
0204 591 0058
Reference Chemistry, 1st Floor Blackfriars Hub
41-43 Friars Bridge Court
Blackfriars Road
London
SE1 8NZ
41-43 Friars Bridge Court
Blackfriars Road
London
SE1 8NZ
Last updated: 09/02/2026
